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Find your Calm in CLEANMOOD
CLEANMOOD® is an Organic 5-HTP ingredient extracted from Griffonia simplicifolia. As a precursor to serotonin production in the brain, 5-HTP supports pathways involved in mood and sleep regulation, with clinical research demonstrating benefits for improved mood, sleep quality, and physiological stress response.*
Stability
Water soluble, pH and heat stable, well tolerated for supplements and functional foods
Clinically Studied
CLEANMOOD® at 150mg has been clinically studied in a randomized, double-blind, placebo-controlled trial to enhance mood and sleep quality in young adults ages 18-40 years old*
Sustainable
We use clean water, clean soil, and zero pesticides throughout the harvesting and manufacturing processes
- CLEANMOOD® Organic 5-HTP
Why Choose CLEANMOOD®?
Clean Label
Clean flavor profile
SA GRAS
Can be used in food, beverages, and dietary supplements
Water Extracted
No harmful solvents used
Plant Based
Plant-based and vegetarian ingredient
Clinically Studied Mood + Sleep Quality Benefits
In the 25-day randomized, double-blind, placebo-controlled study, CLEANMOOD® demonstrated improvements in both psychological distress and sleep quality, with changes observed by Day 13 and becoming more pronounced by Day 25.*
- Improved psychological distress scores measured by DASS-21*
- Improved sleep quality measured by the Pittsburgh Sleep Quality Index (PSQI)*
- Clinical efficacy demonstrated in both capsule and functional food bar formats*
- Clinical evidence supports incorporating CLEANMOOD® into functional foods, including bars, snacks, and other functional wellness formats.*
Supporting a Healthy Physiological Stress Response
Beyond self-reported mood and sleep measures, the clinical study also evaluated morning and evening salivary cortisol, providing a physiological endpoint to complement the DASS-21 and PSQI findings.
After 25 days, CLEANMOOD® groups demonstrated significant reductions in both morning and evening salivary cortisol compared with their respective matched placebo groups.*
- Reduced morning and evening salivary cortisol after 25 days*
- Provides a physiological endpoint complementing the mood and sleep findings*
- Significant differences were observed versus matched placebo for both morning and evening cortisol*
Sustainably Sourced
- Our CLEANMOOD® Organic Griffonia Seed Extract Powder is an herbal extract that comes from the seeds of a Ghanaian plant called Griffonia simplicifolia.
- Griffonia simplicifolia is an evergreen shrub in the Fabaceae family, that is native to west and central Africa.
- Out of care for the natural resources, we only harvest an amount of Griffonia simplicifolia seed that is less than 70% of the total output in the organic area.
CLEANMOOD Gives Back
Donating New Desks and Chairs
NURA donated school supplies, desks, and chairs to improve the learning environment for 76 students. Ruan noted that by equipping Ben and his teachers with better resources, they aim to help students gain skills and confidence to become self-sufficient, compassionate adults.
Support Local Ghanian Workers
Oguaakrom/Nyakuadze D/A Basic School
Donating New Desks and Chairs
NURA donated school supplies, desks, and chairs to improve the learning environment for 76 students. Ruan noted that by equipping Ben and his teachers with better resources, they aim to help students gain skills and confidence to become self-sufficient, compassionate adults.
Support Local Ghanian Workers
Oguaakrom/Nyakuadze D/A Basic School
Featured Prototype
Blood Orange Focus Gummy
- Features Alpha-GPC
- Features L-Theanine
- Features CLEANMOOD® Organic 5-HTP
- Reduced Sugar
- Mood and Focus Support
- Approved for 3 yrs old +
Featured Ingredients: Inulin, Allulose, Alpha-GPC , L-Theanine , Natural Flavor, CLEANMOOD® Organic 5-HTP
What is CLEANMOOD®?
CLEANMOOD® is a certified organic 5-HTP ingredient sourced from Griffonia simplicifolia seeds. It is designed for functional wellness products that support healthy mood, relaxation, stress balance, and sleep quality. Available in a versatile powder form, CLEANMOOD® is suitable for use in dietary supplements, functional foods, and beverages.
How does CLEANMOOD® work?
CLEANMOOD® delivers 5-HTP, a naturally occurring compound that serves as a direct precursor to serotonin production in the body. Serotonin is a key neurotransmitter involved in mood regulation, stress response, relaxation, and healthy sleep patterns. Because 5-HTP works directly within the serotonin pathway, CLEANMOOD® provides a clear, mechanism-based story for brands building products around mood, calm, and sleep.
What is the recommended daily dose of CLEANMOOD®?
What makes CLEANMOOD® different from other calming or mood-support ingredients?
CLEANMOOD® has a specific, well-understood mechanism. As a serotonin precursor, 5-HTP operates directly within a neurochemical pathway rather than providing broad, non-specific relaxation support. This gives brands a more targeted and substantiated positioning story. Beyond mechanism, CLEANMOOD® is differentiated by its organic certification, glyphosate-residue-free status, water extraction process, and non-GMO verification. It is also the only branded 5-HTP sourced from certified organic Griffonia simplicifolia, which adds a clean-label credential that most 5-HTP raw materials cannot match.
Can CLEANMOOD® be used in food and beverage products?
Yes. CLEANMOOD® Organic 5-HTP is designed for formulation versatility across dietary supplements, functional foods, and select beverage applications. Its water solubility, neutral flavor, and heat- and pH-stable properties make it suitable for capsules, powders, functional bars, snacks, and beverage mixes.
A published human clinical trial demonstrated significant improvements in psychological distress and sleep quality when CLEANMOOD® was delivered in both capsule and functional food bar formats, with comparable observed responses under the conditions tested.
For ready-to-drink beverages and other water-based applications, finished-product stability should be validated to confirm 5-HTP retention throughout shelf life. CLEANMOOD® has a stated shelf life of two years in its finished powder form.
Is CLEANMOOD® stable in finished products?
CLEANMOOD® is heat stable, pH stable, and water soluble with a neutral flavor profile, which supports its use across a wide range of product formats including bars, capsules, powders, and shots. These properties make it a practical choice for formulation across functional food and supplement categories. For ready-to-drink or water-based liquid applications, finished-product stability testing is recommended to confirm active 5-HTP retention under your specific storage and processing conditions.
Is CLEANMOOD® safe and well tolerated?
Yes. CLEANMOOD® Organic 5-HTP was well tolerated in a published, randomized, double-blind, placebo-controlled clinical trial involving 80 generally healthy adults ages 18–40. Participants received 150 mg/day of 5-HTP for 25 days, with no serious adverse events or clinically meaningful changes in measured vital signs, hematological parameters, or serum chemistry markers.
5-HTP also has an established history of clinical research. Important considerations include potential gastrointestinal sensitivity at higher doses and avoiding concurrent use with serotonergic medications unless directed by a healthcare professional.
Where does CLEANMOOD® come from, and how is it made?
CLEANMOOD® is sourced from the seeds of Griffonia simplicifolia, a woody climbing shrub native to West and Central Africa and one of the richest natural plant sources of 5-HTP. The seeds are grown under certified organic practices with no synthetic pesticides, herbicides, or glyphosate, and 5-HTP is extracted using a water-based process that preserves the clean-label integrity of the finished ingredient.
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